Our goal is to understand human diseases from molecules and cells to organs and whole body system. We will utilize biochemistry, molecular biology, and genetics to achieve this goal. 

LC domains and Phase Separation

PI: Eiichiro Mori

Members: Hitoki Nanaura, Tomo Shiota

We are working on the biological function of low-complexity (LC) domains, which are found in about 10% of human proteome. 

Our project is part of Brain/MINDS Beyond supported by AMED. 

Organoids and Regeneration

PI: Takeshi K. Matsui

Members: Nobuyuki Eura

To study human diseases at organ level, we combine organoids (organ-in-a-dish from ES/iPS cells) and CRISPR/Cas9 gene editing. 

Cancer and DNA Repair

PI: Yosuke Nakagawa

Members: Shinko Kobashigawa, Soichiro Ito

To improve cancer therapy, we try to understand the underlying mechanism in the cancer cells and tissues. 

HLAs and Regenerative Medicine

PI: Akiko Ishitani

Members: Mari Nakanishi

A major genetic determinant of the immune response in general is contained within the major histocompatibility complex (MHC). In humans, this region includes the classical class I loci human leukocyte antigen (HLA)-A, -B and -C, and non-classical class I genes HLA-E, -F, and -G. One of the major issues in cell transplantation therapies is immune matching, and mismatching in donors and recipients could lead to serious complications. We tackle this fundamental issue by better understanding these HLA genes.