Our goal is to understand human diseases from molecules and cells to organs and whole body system. We will utilize biochemistry, molecular biology, and genetics to achieve this goal.
LC domains and Phase Separation
Members: Eiichiro Mori, Hitoki Nanaura, Tomo Shiota
We are working on the biological function of low-complexity (LC) domains, which are found in about 10% of human proteome.
Cancer and DNA Repair
Members: Yosuke Nakagawa, Soichiro Ito
To improve cancer therapy, we try to understand the underlying mechanism in the cancer cells and tissues.
HLAs and Regenerative Medicine
Members: Akiko Ishitani, Mari Nakanishi
A major genetic determinant of the immune response in general is contained within the major histocompatibility complex (MHC). In humans, this region includes the classical class I loci human leukocyte antigen (HLA)-A, -B and -C, and non-classical class I genes HLA-E, -F, and -G. One of the major issues in cell transplantation therapies is immune matching, and mismatching in donors and recipients could lead to serious complications. We tackle this fundamental issue by better understanding these HLA genes.