Our goal is to understand human diseases from molecules and cells to organs and whole body system. We will utilize biochemistry, molecular biology, and genetics to achieve this goal.
LC domains and Phase Separation
PI: Eiichiro Mori
Members: Hitoki Nanaura, Tomo Shiota
We are working on the biological function of low-complexity (LC) domains, which are found in about 10% of human proteome.
Organoids and Regeneration
PI: Takeshi K. Matsui
Members: Nobuyuki Eura
To study human diseases at organ level, we combine organoids (organ-in-a-dish from ES/iPS cells) and CRISPR/Cas9 gene editing.
Cancer and DNA Repair
PI: Yosuke Nakagawa
Members: Shinko Kobashigawa, Soichiro Ito
To improve cancer therapy, we try to understand the underlying mechanism in the cancer cells and tissues.
HLAs and Regenerative Medicine
PI: Akiko Ishitani
Members: Mari Nakanishi
A major genetic determinant of the immune response in general is contained within the major histocompatibility complex (MHC). In humans, this region includes the classical class I loci human leukocyte antigen (HLA)-A, -B and -C, and non-classical class I genes HLA-E, -F, and -G. One of the major issues in cell transplantation therapies is immune matching, and mismatching in donors and recipients could lead to serious complications. We tackle this fundamental issue by better understanding these HLA genes.