ACHIEVEMENTS

Latest results (preprints)

Oxygen-glucose deprivation and reoxygenation on human cerebral organoids alters expression related to lipid metabolism. Iwasa N, Matsui TK, Morikawa N, Sakaguchi YM, Shiota T, Iguchi N, Nishimura Y, Mori E*, Sugie K*. (*corresponding authors) bioRxiv 2020. doi: 10.1101/2020.03.31.017335

Transiently structured head domains control intermediate filament assembly. Zhou X, Lin Y, Liszczak G, Sysoev V, Sutherland L, Mori E, Murray D, Kato M, Tycko R, McKnight SL. bioRxiv 2020. doi: 10.1101/2020.03.27.012112

Brainstem organoids from human pluripotent stem cells contain neural crest population. Eura N, Matsui TK, Luginbühl J, Matsubayashi M, Nanaura H, Shiota T, Kinugawa K, Iguchi N, Kiriyama T, Zheng C, Kouno T, Lan YJ, Kongpracha P, Wiriyasermkul P, Sakaguchi YM, Nagata R, Komeda T, Morikawa N, Kitayoshi F, Jong M, Kobashigawa S, Nakanishi M, Hasegawa M, Saito Y, Shiromizu T, Nishimura Y, Kasai T, Takeda M, Kobayashi H, Inagaki Y, Tanaka Y, Makinodan M, Kishimoto T, Kuniyasu H, Nagamori S, Muotri AR, Shin JW*, Sugie K*, Mori E* (*corresponding authors) bioRxiv 2019. doi: 10.1101/829275

Human URAT1/SLC22A12 gene promoter is regulated by 27-hydroxycholesterol through estrogen response elements. Matsubayashi M, Sakaguchi YM, Sahara Y, Nanaura H, Kikuchi S, Ashari A, Bui L, Kobashigawa S, Nakanishi M, Nagata R, Matsui TK, Kashino G, Hasegawa M, Takasawa S, Eriguchi M, Tsuruya K, Nagamori S, Sugie K, Nakagawa T, Takasato M, Umetani M*, Mori E*. (*corresponding authors) bioRxiv 2019. doi: 10.1101/827709

Proteolytic Cleavage by Matriptase Exacerbating Kidney Injury: a Novel Therapeutic Target. Ozawa S, Matsubayashi M, Nanaura H, Yanagita M, Mori K, Asanuma K, Kajiwara N, Hayashi K, Ohashi H, Kasahara M, Yokoi H, Kataoka H, Mori E*, Nakagawa T*. (*corresponding authors) bioRxiv 2019. doi: 10.1101/843607

Toxic PR poly-dipeptides encoded by the C9orf72 repeat expansion target Kapβ2 and dysregulate phase separation of low-complexity domains. Nanaura H, Kawamukai H, Fujiwara A, Uehara T, Nakanishi M, Shiota T, Hibino M, Aiba Y, Wiriyasermkul P, Kikuchi S, Nagata R, Matsubayashi M, Nagamori S, Shoji O, Ishimori K, Matsumura H, Sugie K, Saio T*, Yoshizawa T*, Mori E*. (*corresponding authors) bioRxiv 2019. doi: 10.1101/812099

Featured Articles

Biological phase separation: cell biology meets biophysics. Yoshizawa T, Nozawa RS, Jia TZ, Saio T, Mori E*. (*corresponding author) Biophys Rev 2020. doi: 10.1007/s12551-020-00680-x. (review)

Toxic PRn poly-dipeptides encoded by the C9orf72 repeat expansion block nuclear import and export. Shi KY*, Mori E*, Nizami ZF, Lin Y, Kato M, Xiang S, Wu LC, Ding M, Yu Y, Gall JG, McKnight SL. (*equal contribution) Proc Natl Acad Sci U S A 2017; 114(7): E1111-E1117. 

Toxic PR poly-dipeptides encoded by the C9orf72 repeat expansion target LC domain polymers. Lin Y*, Mori E*, Kato M*, Xiang S*, Wu L, Kwon I, McKnight SL. (*equal contribution) Cell 2016; 167(3): 789-802.

The oxygen-rich postnatal environment induces cardiomyocyte cell-cycle arrest through DNA damage response. Puente BN, Kimura W, Muralidhar SA, Moon J, Amatruda JF, Phelps KL, Grinsfelder D, Rothermel BA, Chen R, Garcia JA, Santos CX, Thet S, Mori E, Kinter MT, Rindler PM, Zacchigna S, Mukherjee S, Chen DJ, Mahmoud AI, Giacca M, Rabinovitch PS, Aroumougame A, Shah AM, Szweda LI, Sadek HA. Cell 2014; 157(3): 565-579. 

A method for systematic mapping of protein lysine methylation identifies functions for HP1β in DNA damage response. Liu H, Galka M, Mori E, Liu X, Lin YF, Wei R, Pittock P, Voss C, Dhami G, Li X, Miyaji M, Lajoie G, Chen B, Li SS. Mol Cell 2013; 50(5): 723-735. 

Other Articles

2019

Stress-induced Cellular Senescence Contributes to Chronic Inflammation and Cancer Progression. Kobashigawa S, Sakaguchi YM, Masunaga S, Mori E*. (*corresponding author) Thermal Med 2019; 35(4): 41-58. (review)

Nuclear Foci Assays in Live Cells. Mori E, Asaithamby A. Methods Mol Biol 2019; 1984: 75-85. 

2018

Heat Meets DNA: DNA Damage and Repair. Nakagawa Y, Kajihara A, Kirita T, Mori E*. (*corresponding author) Thermal Med 2018; 34(2):15-22. (review)

Microglia support neural stem cell maintenance and growth. Matsui TK*, Mori E*. (*corresponding authors) Biochem Biophys Res Commun 2018; 503(3): 1880-1884. 

BRCA2 protects mammalian cells from heat shock. Nakagawa Y, Kajihara A, Takahashi A, Murata AS, Matsubayashi M, Ito SS, Ota I, Nakagawa T, Hasegawa M, Kirita T, Ohnishi T, Mori E*. (*corresponding author) Int J Hyperthermia 2018; 34(6): 795-801.

Six-month cultured cerebral organoids from human ES cells contain matured neural cells. Matsui TK, Matsubayashi M, Sakaguchi YM, Hayashi RK, Zheng C, Sugie K, Hasegawa M, Nakagawa T*, Mori E*. (*corresponding authors) Neurosci Lett 2018; 670: 75-82. 

2017

Homologous recombination preferentially repairs heat-induced DNA double-strand breaks in mammalian cells. Takahashi A, Mori E, Nakagawa Y, Kajihara A, Kirita T, Pittman DL, Hasegawa M, Ohnishi T. Int J Hyperthermia 2017; 33(3): 336-342.

2016

Lysines 3241 and 3260 of DNA-PKcs are important for genomic stability and radioresistance. Mori E, Davis AJ, Hasegawa M, Chen DJ. Biochem Biophys Res Commun 2016; 477(2): 235-240. 

2015

FANCD2 influences replication fork processes and genome stability in response to clustered DSBs. Zhu J, Su F, Mukherjee S, Mori E, Hu B, Asaithamby A. Cell Cycle 2015; 14(12): 1809-1822. 

2014

Nonenzymatic role for WRN in preserving nascent DNA strands after replication stress. Su F, Mukherjee S, Yang Y, Mori E, Bhattacharya S, Kobayashi J, Yannone SM, Chen DJ, Asaithamby A. Cell Rep 2014; 9(4): 1387-1401. 

BRCA1 modulates the autophosphorylation status of DNA-PKcs in S phase of the cell cycle. Davis AJ, Chi L, So S, Lee KJ, Mori E, Fattah K, Yang J, Chen DJ. Nucleic Acids Res 2014; 42(18): 11487-11501. 

SUMOylation of ATRIP potentiates DNA damage signaling by boosting multiple protein interactions in the ATR pathway. Wu CS, Ouyang J, Mori E, Nguyen HD, Maréchal A, Hallet A, Chen DJ, Zou L. Genes Dev 2014; 28(13): 1472-1484. 

The BRCA2 gene is a potential molecular target during 5-fluorouracil therapy in human oral cancer cells. Nakagawa Y, Kajihara A, Takahashi A, Kondo N, Mori E, Kirita T, Ohnishi T. Oncol Rep 2014; 31(5): 2001-2006. 

日本語総説・記事・ニュース等

「相分離生物学」誕生秘話:私見. 森 英一朗. 化学工業 2020; 71(4): 247-252. 

相分離生物学の誕生. 白木 賢太郎, 森 英一朗, 吉澤 拓也. 現代化学 2019; 582: 18-24. 

液-液相分離による細胞応答の新展開. 吉澤 拓也, 森 英一朗日本ハイパーサーミア学会・学術報告(ハイパーサーミアに関する最近の話題23)

ES細胞から大脳組織培養. 松井 健, 森 英一朗日本経済新聞(2018年7月23日朝刊)

Grants

2020

KAKENHI Grant-in-Aid for Scientific Research (B), PI: Eiichiro Mori, FY2020-FY2022

KAKENHI Grant-in-Aid for Scientific Research (C), PI: Toshio Mori (CI: Eiichiro Mori), FY2020-FY2022

KAKENHI Grant-in-Aid for Early-Career Scientists, PI: Hitoki Nanaura, FY2020-FY2021

KAKENHI Grant-in-Aid for Early-Career Scientists, PI: Nobuyuki Eura, FY2020-FY2022

AMED Practical Research Project for Rare / Intractable Diseases, PI: Tomohide Saio (CI: Hitoki Nanaura), FY2020-FY2022

2019

Tokyo Biochemical Research Foundation, PI: Sotaro Kikuchi, FY2019

Uehara Memorial Foundation, PI: Sotaro Kikuchi, FY2019

KAKENHI Grant-in-Aid for Research Activity Start-up, PI: Mari Nakanishi, FY2019-FY2020

KAKENHI Grant-in-Aid for Research Activity Start-up, PI: Kaoru Kinugawa, FY2019-FY2020

KAKENHI Grant-in-Aid for Challenging Research (Exploratory), PI: Akio Tsuboi (CI: Eiichiro Mori), FY2019-FY2021

Novartis Research Grants, PI: Eiichiro Mori, FY2019

Novartis Research Grants, PI: Hitoki Nanaura, FY2019

Nara Medical University Grant-in-Aid for Young Scientists, PI: Nobuyuki Eura, FY2019

KAKENHI Grant-in-Aid for Scientific Research (B), PI: Akio Tsuboi (CI: Eiichiro Mori), FY2019-FY2021

KAKENHI Grant-in-Aid for Scientific Research (C), PI: Tadaaki Kirita (CI: Eiichiro Mori), FY2019-FY2022

KAKENHI Grant-in-Aid for Scientific Research (C), PI: Takao Kiriyama (CI: Takeshi Matsui), FY2019-FY2021

KAKENHI Grant-in-Aid for Scientific Research (C), PI: Shinko Kobashigawa (CI: Eiichiro Mori), FY2019-FY2022

KAKENHI Grant-in-Aid for Early-Career Scientists, PI: Naohiko Iguchi, FY2019-FY2022

KAKENHI Grant-in-Aid for Early-Career Scientists, PI: Tomo Shiota, FY2019-FY2021

KAKENHI Grant-in-Aid for Early-Career Scientists, PI: Takeshi Matsui, FY2019-FY2020

2018

Nara Medical University Grant-in-Aid for Young Scientists, PI: Takeshi Matsui, FY2018

Nara Medical University Grant-in-Aid for Collaborative Research Projects, PI: Hiroki Kuniyasu (CI: Eiichiro Mori), FY2018-FY2019

AMED Osaka University Seeds (A), PI: Takeshi Matsui, FY2019

AMED The Program for Technological Innovation of Regenerative Medicine, PI: Takeshi Matsui, FY2019-FY2021

Sumitomo Dainippon Pharma Research Grant, PI: Takeshi Matsui, FY2018

AMED Brain/MINDS Beyond, PI: Eiichiro Mori, FY2018-FY2020

Terumo Foundation for Life Sciences and Arts, PI: Eiichiro Mori, FY2018

MSD Life Science Foundation, PI: Eiichiro Mori, FY2018

SENSHIN Medical Research Foundation, PI: Eiichiro Mori, FY2018

Naito Foundation, PI: Eiichiro Mori, FY2018

Mochida Memorial Foundation for Medical and Pharmaceutical Research, PI: Eiichiro Mori, FY2018

KAKENHI Grant-in-Aid for Research Activity Start-up, PI: Hitoki Nanaura, FY2018-FY2019

Takeda Science Foundation, PI: Takeshi Matsui, FY2018

Nara Kidney Disease Research Foundation, PI: Eiichiro Mori, FY2018

Novartis Research Grants, PI: Eiichiro Mori, FY2018

Novartis Research Grants, PI: Nobuyuki Eura, FY2018

KAKENHI Grant-in-Aid for Scientific Research (B), PI: Masatoshi Hasegawa (CI: Eiichiro Mori), FY2018-FY2021

KAKENHI Grant-in-Aid for Early-Career Scientists, PI: Yosuke Nakagawa, FY2018-FY2020

2017

Nakatomi Foundation, PI: Eiichiro Mori, FY2017

Konica Minolta Science and Technology Foundation, PI: Eiichiro Mori, FY2017

Uehara Memorial Foundation, PI: Eiichiro Mori, FY2017

Kanzawa Medical Research Foundation, PI: Eiichiro Mori, FY2017

Takeda Science Foundation, PI: Eiichiro Mori, FY2017

Nara Medical University Grant-in-Aid for Collaborative Research Projects, PI: Kazuma Sugie (CI: Eiichiro Mori), FY2017-FY2018

KAKENHI Grant-in-Aid for Research Activity Start-up, PI: Eiichiro Mori, FY2017-FY2018

Unrestricted Funds

Koseikai, PI: Eiichiro Mori, FY2018

KTX Corp., PI: Eiichiro Mori, FY2017-FY2018

Awards