ACHIEVEMENTS

Latest results (preprints)

Comparative analysis of human brain organoids of brainstem and midbrain at single-cell resolution. Kinugawa K, Luginbühl J, Matsui TK, Eura N, Sakaguchi YM, Shin JW, Sugie K, Schwamborn JC, Mori E*. (*corresponding author) bioRxiv 2020. doi: 10.1101/2020.09.02.279380

Featured Articles

C9orf72-derived arginine-rich poly-dipeptides impede phase modifiers. Nanaura H, Kawamukai H, Fujiwara A, Uehara T, Aiba Y, Nakanishi M, Shiota T, Hibino M, Wiriyasermkul P, Kikuchi S, Nagata R, Matsubayashi M, Shinkai Y, Niwa T, Mannen T, Morikawa N, Iguchi N, Kiriyama T, Morishima K, Inoue R, Sugiyama M, Oda T, Kodera N, Toma-Fukai S, Sato M, Taguchi H, Nagamori S, Shoji O, Ishimori K, Matsumura H, Sugie K, Saio T*, Yoshizawa T*, Mori E*. (*corresponding authors) Nat Commun 2021; 12(1): 5301. 

Transiently structured head domains control intermediate filament assembly. Zhou X, Lin Y, Kato M, Mori E, Liszczak G, Sutherland L, Sysoev V, Murray D, Tycko R, McKnight SL. Proc Natl Acad Sci U S A 2021; 118(8): e2022121118. 

Toxic PRn poly-dipeptides encoded by the C9orf72 repeat expansion block nuclear import and export. Shi KY*, Mori E*, Nizami ZF, Lin Y, Kato M, Xiang S, Wu LC, Ding M, Yu Y, Gall JG, McKnight SL. (*equal contribution) Proc Natl Acad Sci U S A 2017; 114(7): E1111-E1117. 

Toxic PR poly-dipeptides encoded by the C9orf72 repeat expansion target LC domain polymers. Lin Y*, Mori E*, Kato M*, Xiang S*, Wu L, Kwon I, McKnight SL. (*equal contribution) Cell 2016; 167(3): 789-802.

The oxygen-rich postnatal environment induces cardiomyocyte cell-cycle arrest through DNA damage response. Puente BN, Kimura W, Muralidhar SA, Moon J, Amatruda JF, Phelps KL, Grinsfelder D, Rothermel BA, Chen R, Garcia JA, Santos CX, Thet S, Mori E, Kinter MT, Rindler PM, Zacchigna S, Mukherjee S, Chen DJ, Mahmoud AI, Giacca M, Rabinovitch PS, Aroumougame A, Shah AM, Szweda LI, Sadek HA. Cell 2014; 157(3): 565-579. 

A method for systematic mapping of protein lysine methylation identifies functions for HP1β in DNA damage response. Liu H, Galka M, Mori E, Liu X, Lin YF, Wei R, Pittock P, Voss C, Dhami G, Li X, Miyaji M, Lajoie G, Chen B, Li SS. Mol Cell 2013; 50(5): 723-735. 

Other Articles

2022

C9orf72-derived proline:arginine poly-dipeptides modulate cytoskeleton and mechanical stress response.  Shiota T, Nagata R, Kikuchi S, Nanaura H, Matsubayashi M, Nakanishi M, Kobashigawa S, Isozumi N, Kiriyama T, Nagayama K, Sugie K, Yamashiro Y*, Mori E*. (*corresponding authors) Front Cell Dev Biol 2022; 10: 750829.

2021

Olig2-astrocytes express neutral amino acid transporter SLC7A10 (Asc-1) in the adult brain. Tatsumi T, Kinugawa K, Isonishi A, Kitabatake M, Okuda H, Takemura S, Tanaka T, Mori E, Wanaka A. Mol Brain 2021; 14: 163.

Ras-like Gem GTPase induced by Npas4 promotes activity-dependent neuronal tolerance for ischemic stroke. Takahashi H, Asahina R, Fujioka M, Matsui TK, Kato S, Mori E, Hioki H, Yamamoto T, Kobayashi K, Tsuboi A. Proc Natl Acad Sci U S A 2021; 118(32): e2018850118. 

Gene expression profiles of human cerebral organoids identify PPAR pathway and PKM2 as key markers for oxygen-glucose deprivation and reoxygenation. Iwasa N, Matsui TK, Iguchi N, Kinugawa K, Morikawa N, Sakaguchi YM, Shiota T, Kobashigawa S, Nakanishi M, Matsubayashi M, Nagata R, Kikuchi S, Tanaka T, Eura N, Kiriyama T, Izumi T, Saito K, Kataoka K, Saito Y, Kimura W, Wanaka A, Nishimura Y, Mori E*, Sugie K*. (*corresponding authors) Front Cell Neurosci 2021; 15: 605030.

27-Hydroxycholesterol regulates human SLC22A12 gene expression through estrogen receptor action. Matsubayashi M, Sakaguchi YM, Sahara Y, Nanaura H, Kikuchi S, Ashari A, Bui L, Kobashigawa S, Nakanishi M, Nagata R, Matsui TK, Kashino G, Hasegawa M, Takasawa S, Eriguchi M, Tsuruya K, Nagamori S, Sugie K, Nakagawa T, Takasato M, Umetani M*, Mori E*. (*corresponding authors) FASEB J 2021; 35(1): e21262.

2020

Proteolytic cleavage of Podocin by Matriptase exacerbates podocyte injury. Ozawa S, Matsubayashi M, Nanaura H, Yanagita M, Mori K, Asanuma K, Kajiwara N, Hayashi K, Ohashi H, Kasahara M, Yokoi H, Kataoka H, Mori E*, Nakagawa T*. (*corresponding authors) J Biol Chem 2020; 295(47): 16002-16012. 

Single-cell transcriptomics reveals multiple neuronal cell types in human midbrain-specific organoids. Smits LM, Magni S, Kinugawa K, Grzyb K, Luginbühl J, Soler SS, Bolognin S, Shin JW, Mori E, Skupin A, Schwamborn JC. Cell Tissue Res 2020; 382(3): 463-476. 

Inhibition of the ATR kinase enhances 5-FU sensitivity independently of non-homologous end-joining and homologous recombination repair pathways. Ito SS, Nakagawa Y, Matsubayashi M, Sakaguchi YM, Kobashigawa S, Matsui TK, Nanaura H, Nakanishi M, Kitayoshi F, Kikuchi S, Kajihara A, Tamaki S, Sugie K, Kashino G, Takahashi A, Hasegawa M, Mori E*, Kirita T*. (*corresponding authors) J Biol Chem 2020; 295(37): 12946-12961.

RT-qPCR analyses on the osteogenic differentiation from human iPS cells: An investigation of reference genes. Okamura K, Inagaki Y, Matsui TK, Matsubayashi M, Komeda T, Ogawa M, Mori E, Tanaka Y. Sci Rep 2020; 10(1): 11748. 

Brainstem organoids from human pluripotent stem cells. Eura N, Matsui TK, Luginbühl J, Matsubayashi M, Nanaura H, Shiota T, Kinugawa K, Iguchi N, Kiriyama T, Zheng C, Kouno T, Lan YJ, Kongpracha P, Wiriyasermkul P, Sakaguchi YM, Nagata R, Komeda T, Morikawa N, Kitayoshi F, Jong M, Kobashigawa S, Nakanishi M, Hasegawa M, Saito Y, Shiromizu T, Nishimura Y, Kasai T, Takeda M, Kobayashi H, Inagaki Y, Tanaka Y, Makinodan M, Kishimoto T, Kuniyasu H, Nagamori S, Muotri AR, Shin JW*, Sugie K*, Mori E*. (*corresponding authors) Front Neurosci 2020; 14: 538. 

Biological phase separation: cell biology meets biophysics. Yoshizawa T, Nozawa RS, Jia TZ, Saio T, Mori E*. (*corresponding author) Biophys Rev 2020; 12(2): 519-539. (review)

2019

Stress-induced cellular senescence contributes to chronic inflammation and cancer progression. Kobashigawa S, Sakaguchi YM, Masunaga S, Mori E*. (*corresponding author) Thermal Med 2019; 35(4): 41-58. (review)

Nuclear foci assays in live cells. Mori E, Asaithamby A. Methods Mol Biol 2019; 1984: 75-85. 

2018

Heat Meets DNA: DNA Damage and Repair. Nakagawa Y, Kajihara A, Kirita T, Mori E*. (*corresponding author) Thermal Med 2018; 34(2): 15-22. (review)

Microglia support neural stem cell maintenance and growth. Matsui TK*, Mori E*. (*corresponding authors) Biochem Biophys Res Commun 2018; 503(3): 1880-1884. 

BRCA2 protects mammalian cells from heat shock. Nakagawa Y, Kajihara A, Takahashi A, Murata AS, Matsubayashi M, Ito SS, Ota I, Nakagawa T, Hasegawa M, Kirita T, Ohnishi T, Mori E*. (*corresponding author) Int J Hyperthermia 2018; 34(6): 795-801.

Six-month cultured cerebral organoids from human ES cells contain matured neural cells. Matsui TK, Matsubayashi M, Sakaguchi YM, Hayashi RK, Zheng C, Sugie K, Hasegawa M, Nakagawa T*, Mori E*. (*corresponding authors) Neurosci Lett 2018; 670: 75-82. 

2017

Homologous recombination preferentially repairs heat-induced DNA double-strand breaks in mammalian cells. Takahashi A, Mori E, Nakagawa Y, Kajihara A, Kirita T, Pittman DL, Hasegawa M, Ohnishi T. Int J Hyperthermia 2017; 33(3): 336-342.

2016

Lysines 3241 and 3260 of DNA-PKcs are important for genomic stability and radioresistance. Mori E, Davis AJ, Hasegawa M, Chen DJ. Biochem Biophys Res Commun 2016; 477(2): 235-240. 

2015

FANCD2 influences replication fork processes and genome stability in response to clustered DSBs. Zhu J, Su F, Mukherjee S, Mori E, Hu B, Asaithamby A. Cell Cycle 2015; 14(12): 1809-1822. 

2014

Nonenzymatic role for WRN in preserving nascent DNA strands after replication stress. Su F, Mukherjee S, Yang Y, Mori E, Bhattacharya S, Kobayashi J, Yannone SM, Chen DJ, Asaithamby A. Cell Rep 2014; 9(4): 1387-1401. 

BRCA1 modulates the autophosphorylation status of DNA-PKcs in S phase of the cell cycle. Davis AJ, Chi L, So S, Lee KJ, Mori E, Fattah K, Yang J, Chen DJ. Nucleic Acids Res 2014; 42(18): 11487-11501. 

SUMOylation of ATRIP potentiates DNA damage signaling by boosting multiple protein interactions in the ATR pathway. Wu CS, Ouyang J, Mori E, Nguyen HD, Maréchal A, Hallet A, Chen DJ, Zou L. Genes Dev 2014; 28(13): 1472-1484. 

The BRCA2 gene is a potential molecular target during 5-fluorouracil therapy in human oral cancer cells. Nakagawa Y, Kajihara A, Takahashi A, Kondo N, Mori E, Kirita T, Ohnishi T. Oncol Rep 2014; 31(5): 2001-2006. 

日本語総説・記事・ニュース等

Biological Phase Separation. Mori E, Jia TZ. Front Genet 2022; 13: 895689. (editorial)

分子シャペロンによる液–液相分離制御. 川越 聡一郎, 森 英一朗, 齋尾 智英. Thermal Med 2021; 37(2): 31-44. (review)

細胞内「相分離」. 白木 賢太郎, 森 英一朗, 吉澤 拓也, 遠藤 斗志也. 読売新聞（2020年12月6日朝刊）

Low-complexityドメインとクロスβ繊維（16章）. 森 英一朗, 加藤 昌人. 相分離生物学の全貌（現代化学増刊46, 白木 賢太郎（編））

分子シャペロン研究は新たなるステージへ. 齋尾 智英, 森 英一朗. 日本ハイパーサーミア学会・学術報告（ハイパーサーミアに関する最近の話題49）

相分離生物学：相分離メガネのススメ（特集）. 森 英一朗（編）. 生物工学会誌 2020; 98(5): 228-254. 

「相分離生物学」誕生秘話：私見. 森 英一朗. 化学工業 2020; 71(4): 247-252. 

相分離生物学の誕生. 白木 賢太郎, 森 英一朗, 吉澤 拓也. 現代化学 2019; 582: 18-24. 

液-液相分離による細胞応答の新展開. 吉澤 拓也, 森 英一朗. 日本ハイパーサーミア学会・学術報告（ハイパーサーミアに関する最近の話題23）

ＥＳ細胞から大脳組織培養. 松井 健, 森 英一朗. 日本経済新聞（2018年7月23日朝刊）

＜報告＞日本宇宙生物科学会第31回大会 印象記. 森 英一朗. 放射線生物研究 2017; 52(4): 452-455. 

＜追悼＞大西武雄先生追悼文集. 松本 義久, 藤堂 剛, 神谷 研二, 田中 良明, 井尻 憲一, 平岡 真寛, 米井 脩治, 内海 博司, 森 英一朗, 高橋昭久. 放射線生物研究 2017; 52(4): 426-451. 

Takeo Ohnishi, PhD, 1944-2017. Takahashi A, Mori E, Ohnishi K, Matsumoto H. Radiat Res 2017; 188(4): 465-467. 

Grants

2021

Takeda Science Foundation, PI: Eiichiro Mori, FY2021-FY2023

KAKENHI Grant-in-Aid for Challenging Research (Exploratory), PI: Yoshito Yamashiro (CI: Eiichiro Mori), FY2021-FY2022

AMED Practical Research Project for Life-Style related Diseases including Cardiovascular Diseases and Diabetes Mellitus, PI: Yoshito Yamashiro (CI: Eiichiro Mori), FY2021-FY2023

AMED Project for Psychiatric and Neurological Disorders, PI: Eiichiro Mori, FY2021-FY2024

KAKENHI Grant-in-Aid for Early-Career Scientists, PI: Sotaro Kikuchi, FY2021-FY2022

Joint Research Programs of the Institute of Advanced Medical Sciences at Tokushima University, PI: Eiichiro Mori (host: Tomohide Saio), FY2021

AMED Practical Research Project for Rare/Intractable Diseases, PI: Takuya Yoshizawa (CI: Sotaro Kikuchi), FY2021-FY2023

2020

Nara Medical University Grant-in-Aid for Young Scientists, PI: Sotaro Kikuchi, FY2020

KAKENHI Grant-in-Aid for Scientific Research (B), PI: Eiichiro Mori, FY2020-FY2022

KAKENHI Grant-in-Aid for Scientific Research (C), PI: Toshio Mori (CI: Eiichiro Mori), FY2020-FY2022

KAKENHI Grant-in-Aid for Scientific Research (C), PI: Ichiro Ota (CI: Eiichiro Mori), FY2020-FY2022

KAKENHI Grant-in-Aid for Early-Career Scientists, PI: Hitoki Nanaura, FY2020-FY2021

KAKENHI Grant-in-Aid for Early-Career Scientists, PI: Nobuyuki Eura, FY2020-FY2022

AMED Practical Research Project for Rare/Intractable Diseases, PI: Tomohide Saio (CI: Hitoki Nanaura), FY2020-FY2022

2019

Tokyo Biochemical Research Foundation, PI: Sotaro Kikuchi, FY2019

Uehara Memorial Foundation, PI: Sotaro Kikuchi, FY2019

KAKENHI Grant-in-Aid for Research Activity Start-up, PI: Mari Nakanishi, FY2019-FY2020

KAKENHI Grant-in-Aid for Research Activity Start-up, PI: Kaoru Kinugawa, FY2019-FY2020

KAKENHI Grant-in-Aid for Challenging Research (Exploratory), PI: Akio Tsuboi (CI: Eiichiro Mori), FY2019-FY2021

Novartis Research Grants, PI: Eiichiro Mori, FY2019

Novartis Research Grants, PI: Hitoki Nanaura, FY2019

Nara Medical University Grant-in-Aid for Young Scientists, PI: Nobuyuki Eura, FY2019

KAKENHI Grant-in-Aid for Scientific Research (B), PI: Akio Tsuboi (CI: Eiichiro Mori), FY2019-FY2021

KAKENHI Grant-in-Aid for Scientific Research (C), PI: Tadaaki Kirita (CI: Eiichiro Mori), FY2019-FY2022

KAKENHI Grant-in-Aid for Scientific Research (C), PI: Takao Kiriyama (CI: Takeshi Matsui), FY2019-FY2021

KAKENHI Grant-in-Aid for Scientific Research (C), PI: Shinko Kobashigawa (CI: Eiichiro Mori), FY2019-FY2022

KAKENHI Grant-in-Aid for Early-Career Scientists, PI: Naohiko Iguchi, FY2019-FY2022

KAKENHI Grant-in-Aid for Early-Career Scientists, PI: Tomo Shiota, FY2019-FY2021

KAKENHI Grant-in-Aid for Early-Career Scientists, PI: Takeshi Matsui, FY2019-FY2020

AMED Osaka University Seeds (A), PI: Takeshi Matsui, FY2019

AMED The Program for Technological Innovation of Regenerative Medicine, PI: Takeshi Matsui, FY2019-FY2021

2018

Nara Medical University Grant-in-Aid for Young Scientists, PI: Takeshi Matsui, FY2018

Nara Medical University Grant-in-Aid for Collaborative Research Projects, PI: Hiroki Kuniyasu (CI: Eiichiro Mori), FY2018-FY2019

Sumitomo Dainippon Pharma Research Grant, PI: Takeshi Matsui, FY2018

AMED Brain/MINDS Beyond, PI: Eiichiro Mori, FY2018-FY2020

Terumo Foundation for Life Sciences and Arts, PI: Eiichiro Mori, FY2018

MSD Life Science Foundation, PI: Eiichiro Mori, FY2018

SENSHIN Medical Research Foundation, PI: Eiichiro Mori, FY2018

Naito Foundation, PI: Eiichiro Mori, FY2018

Mochida Memorial Foundation for Medical and Pharmaceutical Research, PI: Eiichiro Mori, FY2018

KAKENHI Grant-in-Aid for Research Activity Start-up, PI: Hitoki Nanaura, FY2018-FY2019

Takeda Science Foundation, PI: Takeshi Matsui, FY2018

Nara Kidney Disease Research Foundation, PI: Eiichiro Mori, FY2018

Novartis Research Grants, PI: Eiichiro Mori, FY2018

Novartis Research Grants, PI: Nobuyuki Eura, FY2018

KAKENHI Grant-in-Aid for Scientific Research (B), PI: Masatoshi Hasegawa (CI: Eiichiro Mori), FY2018-FY2021

KAKENHI Grant-in-Aid for Early-Career Scientists, PI: Yosuke Nakagawa, FY2018-FY2020

2017

Nakatomi Foundation, PI: Eiichiro Mori, FY2017

Konica Minolta Science and Technology Foundation, PI: Eiichiro Mori, FY2017

Uehara Memorial Foundation, PI: Eiichiro Mori, FY2017

Kanzawa Medical Research Foundation, PI: Eiichiro Mori, FY2017

Takeda Science Foundation, PI: Eiichiro Mori, FY2017

Nara Medical University Grant-in-Aid for Collaborative Research Projects, PI: Kazuma Sugie (CI: Eiichiro Mori), FY2017-FY2018

KAKENHI Grant-in-Aid for Research Activity Start-up, PI: Eiichiro Mori, FY2017-FY2018

Unrestricted Funds

Koseikai, PI: Eiichiro Mori, FY2018

KTX Corp., PI: Eiichiro Mori, FY2017-FY2018

Awards

Riko Nagata, Itsukashi Award for outstanding research activity, Nara Medical University, 2022.

Hitoki Nanaura, The Best Thesis Award, Nara Medical University Graduate School of Medicine, 2022. 

Yoshihiko Sakaguchi, Itsukashi Award for outstanding research activity, Nara Medical University, 2021.

Masaya Matsubayashi, The Best Thesis Award, Nara Medical University Graduate School of Medicine, 2021. 

Yoshihiko Sakaguchi, Poster Presentation Award, Japan Transporter Research Association Kanto-Bukai 2020, 2020.